Neuroendocrine Cell Hyperplasia of Infancy: Diagnosis With High-Resolution CT
نویسندگان
چکیده
منابع مشابه
Familial neuroendocrine cell hyperplasia of infancy.
BACKGROUND Neuroendocrine cell hyperplasia of infancy (NEHI) is a recently described children's interstitial lung disease (chILD) disorder of unknown etiology. It manifests clinically with tachypnea, retractions, hypoxemia, and crackles. The characteristic radiographic appearance consists of pulmonary hyperexpansion and ground-glass densities on high-resolution computed tomography (HRCT). Lung ...
متن کاملThe role of high-resolution chest CT in the diagnosis of neuroendocrine cell hyperplasia of infancy – A rare form of pediatric interstitial lung disease
Interstitial lung disease (ILD) is rare in infancy or early childhood. Differentiating between the different types of ILD is important for reasons of treatment, monitoring of clinical course and prognosis. We present a case of a 5-month old female with tachypnea and hypoxemia. The clinical suspicion of neuroendocrine cell hyperplasia of infancy (NEHI) was confirmed by high-resolution chest CT a...
متن کاملPersistent tachypnea of infancy is associated with neuroendocrine cell hyperplasia.
We sought to determine the clinical course and histologic findings in lung biopsies from a group of children who presented with signs and symptoms of interstitial lung disease (ILD) without identified etiology. Patients were identified from the pathology files at the Texas Children's Hospital who presented below age 2 years with persistent tachypnea, hypoxia, retractions, or respiratory crackle...
متن کاملNeuroendocrine cell distribution and frequency distinguish neuroendocrine cell hyperplasia of infancy from other pulmonary disorders.
BACKGROUND The diagnostic gold standard for neuroendocrine cell hyperplasia of infancy (NEHI) is demonstration of increased numbers of neuroendocrine cells (NECs) amid otherwise near-normal lung histology. Typical clinical and radiographic features often are present. However, NECs are also increased after lung injury and in other disorders, which can complicate biopsy specimen interpretation an...
متن کاملA mutation in TTF1/NKX2.1 is associated with familial neuroendocrine cell hyperplasia of infancy.
BACKGROUND Neuroendocrine cell hyperplasia of infancy (NEHI) is a childhood diffuse lung disease of unknown etiology. We investigated the mechanism for lung disease in a subject whose clinical, imaging, and lung biopsy specimen findings were consistent with NEHI; the subject's extended family and eight other unrelated patients with NEHI were also investigated. METHODS The proband's lung biops...
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ژورنال
عنوان ژورنال: American Journal of Roentgenology
سال: 2010
ISSN: 0361-803X,1546-3141
DOI: 10.2214/ajr.09.2743